So in preparation for Mass Effect 3 I was playing through ME2 again to update my old characters. And I rediscovered one of the many, many, many reasons why I hate Mass Effect 2.
Cintiq, PS (drawing & coloring), Illustrator (for dialogue), Flash (logo)
EDIT: I'm an idiot. The cintiq 12wx has terrible color, but I had my laptop calibrated wrong too, so everything turned out desaturated when I looked on my desktop at home. I think this fixes everything.